Gopal Krishna R Dhondalay PhD
Data Scientist / Bioinformatician / Computational Biologist / Human Geneticist
Work experience
Bioinformatics Data Scientist Imperial College London, UK
​06/2021 - Till date Dept. of Metabolism, Digestion & Reproduction
In this current tenure, I am responsible for developing bioinformatics data analysis pipelines for transcriptomic involving bulk RNAseq, scRNAseq, and whole-exome sequencing in the context of alcoholic hepatitis, diabetes and B-cell lymphomas. To achieve these I am incorporating statistical methods, biological model fitting and programming languages such as R and Python.
Research Engineer - Bioinformatics Stanford University, USA
03/2017 - 11/2020 Sean N. Parker Centre for Allergy and Asthma Research
Primary responsibilities included bioinformatics pipeline establishment and data analysis of Next Generation Sequencing data (RNA-seq, ATAC-seq, TCR-seq). Application of biological model fitting and statistical inferencing of the clinical data. I utilized programming in R, PERL, Bash, and Python.
Visiting Scientist - Bioinformatics Welcome Sanger Institute, UK
04/2016 - 10/2016
During this tenure, the responsibilities included developing and standardizing the bioinformatics pipeline and data analysis of Next Generation Sequencing datasets on Sanger's High-performance Parallel Computing infrastructure. I used the bash and Linux command-line programming to fulfill project needs.
Postdoc Research Associate - Bioinformatics University of Cambridge, UK
02/2015 - 10/2016 Gurdon Institute, Cancer Research UK / Wellcome Trust Centre
The responsibilities include NGS data analysis of DNA-seq and RNA-seq for identification of mutational signatures, synthetic lethal interactions, differentially expressed genes, and functionally enriched Gene Ontology terms for DNA damage and repair genes.
Postdoc Research Associate - Bioinformatics Imperial College of London, UK
12/2013 - 01/2015 National Heart & Lung Institute, ICTEM, Hammersmith Campus
The main responsibility in this full time tenure was to develop bioinformatic analysis of Single-cell genomics and miRNAs from cardiovascular systems extensively using R programming skills. The responsibilities also include single-cell transcriptomic data analysis along with single-cell RT-PCR data analysis.
Research Assistant (Part-time) Nottingham Trent University, UK
04/2013 - 08/2013 Department of Bioinformatics
In this part-time tenure, the responsibilities undertaken are development of computational methods for analyzing genomic and proteomic high-throughput data and network inferencing of potential biological markers in breast cancer. The tenure also has potentials for high impact publications.
Research Associate Nottingham Trent University, UK
09/2010 - 12/2011 Department of Bioinformatics
I worked and successfully completed a collaborative project between Bioinformatics department of Nottingham Trent University and University College of London. Project's objective being investigation of physical bio-processing parameters influence on cellular quality and shear stress response using micro scaled down strategy on human prostrate P4E6 cell lines, potentially used as single cell vaccination.
Research Associate Triesta Sciences (INDIA) Pvt. Ltd.
07/2008 - 11/2009 R & D Division
It was a great opportunity to be a part of R & D team of a cancer hospital network. The responsibilities in the tenure included molecular diagnosis, molecular cytogenetic (FISH) and conventional cytogenetic diagnosis for leukemia and breast carcinoma, tissue culture maintenance and general laboratory working. Also undertook supervision of under-graduate and post-graduate student projects.
Junior Research Fellow N.I.M.H.A.N.S., India
​09/2007 - 05/2008 Department of Human Genetics
I was a member of a team to establish a renovated lab and a tissue culture facility. Working in a team, I was responsible for standardization of protocols and continuing the conventional cytogenetic diagnosis for mental disorders.
Research Assistant sVYASA Research Foundation, India
09/2006 - 08/2007
I worked very enthusiastically in a project to investigate the physiological and hormonal changes caused by stressful working and the intervention of Laughter Yoga by Dr Madan Kataria for the affected. The responsibilities included recruitment of individuals, sample collection, physiological and biological investigations, data generation and data analysis.